
This filling combo takes pizza and casserole to new heights in one meaty masterpiece. I whipped this up for a neighborhood potluck, and now it's the dish everyone begs me to make. It packs all the pizza goodness you crave with that warm, homey casserole feel. The way the flavors stack up reminds me of my neighborhood pizza joint, but it's got that special touch only home cooking delivers.
This dish has become the star of our family get-togethers over the years. When that cheese starts to stretch and the smell fills up the kitchen, everyone shows up at the table before I can even pull it from the oven.
Key Ingredients Breakdown
- Ground beef: Go for 85% lean to get great taste without swimming in grease. Pick meat that's bright red and freshly ground
- Italian sausage: This gives amazing flavor depth. Pick mild or spicy depending on what you like
- Pepperoni: Grab the thick-cut, quality stuff for better bite and richer taste
- Mozzarella cheese: Shred it yourself for the best melty goodness. Skip the pre-shredded bags
- Pizza sauce: Choose one with tomato and basil for that real pizza shop taste and thicker texture
Making Your Masterpiece
- Getting The Oven Ready:
- First, heat your oven to 425°F. You need this high heat to get that crust nice and crispy with perfectly melty cheese. While it warms up, give your 9x13 baking dish a good coating of cooking spray, making sure to hit the sides too.
- Cooking The Meat:
- Get a big skillet hot over medium-high heat. Throw in your ground beef and sausage, breaking it up as it cooks. Keep at it until you don't see any pink, usually 8-10 minutes. Then drain off the fat so your casserole won't turn out greasy.
- Building Flavor:
- Toss your chopped pepperoni into the meat mix. Sprinkle the flour and Italian seasoning over everything, stirring the whole time so it doesn't clump. This step makes a rich base that'll thicken your sauce just right.
- Making The Sauce:
- Now pour in the tomato basil sauce and stir it into your seasoned meat. Let it come to a light boil, giving all those flavors time to mix and the sauce time to thicken a bit. This takes around 5 minutes.
- Putting It Together:
- Dump your meat sauce into the prepared baking dish and spread it out evenly. Cover it with a thick layer of mozzarella. Then carefully unroll the pizza dough on top, gently pulling it to reach the edges.

My Nonna always made us wait before cutting into any casserole. That little bit of patience means the layers can set up properly and your serving won't turn into a runny mess on the plate.
Tasty Pairings
Serve this hearty dish with a crunchy Caesar salad and some buttery garlic bread. Want a full dinner? Add some roasted veggies on the side. And nothing goes better with it than a glass of bold red wine to match those rich flavors.
Mix It Up
- Take it to the next level with some mushrooms cooked till soft, onions browned till sweet, or colorful roasted peppers between the meat and cheese
- Switch up your cheeses with some provolone or fontina in the mix
- Tuck some fresh basil under the pizza dough for a burst of herb flavor
Keeping Leftovers Fresh
Store what's left in the fridge, covered well, for up to 4 days. When you want more, heat single portions in a 350°F oven for about 15 minutes to keep that crust crispy. Try not to use the microwave if you can help it, or your crust will get soggy.

This loaded pizza casserole has turned into my claim to fame at every potluck, always getting tons of compliments and recipe requests. Something magical happens when you mix three kinds of meat with gooey cheese and that crispy crust. It's the kind of food that brings folks together around the table. Just goes to show that sometimes two good things make something even more amazing when combined.
Frequently Asked Questions
- → Can I make this bake in advance?
- Sure, you can prep the meat sauce ahead, but hold off on adding the crust until baking time for the best texture.
- → What else can I use for the crust?
- Crescent rolls or even biscuit dough work just as well and give a soft finish.
- → Can I throw in veggies?
- Absolutely. Stir in cooked peppers, onions, or mushrooms to amp up the flavor.
- → What's the best way to store extras?
- Pop leftovers in the fridge with a cover for up to 3 days. Reheat in the oven so the crust stays crisp.
- → Can this go in the freezer?
- Freeze it without the crust for up to 3 months. Add a fresh topping before sticking it in the oven.